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The pre-benzodiazepine era, in J Psychoactive Drugs, 15/1983, p.9-13. In Br J Clin Pharmacol, 2 / 2007, p.210-8.įireplace I Shaskan D: Death due to massive overdose of meprobamate, in Am J Psychiatry, 115/1959, S.1123-4. Carisoprodol use and abuse in Norway. A pharmacoepidemiological study. The trade name for the launch of carisoprodol soma 1959. The Greek word soma means body. The name Soma, however, is also the name of a fictional drug in Aldous Huxley's novel Brave New World of 1932. was the substitution of a hydrogen atom with an isopropyl group at one of the two carbamyl nitrogen atoms in a molecule of the intention to get with new pharmacological properties. Berger at Wallace Laboratories. The development was based on meprobamate. pharmacologists to discuss the newly developed drug Carisoprodol. Originally it was thought that carisoprodol has antiseptic, but then discovered the central muscle relaxant properties.
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On 1 June 1959 gathered at Wayne State University in Detroit / Michigan several U.S.
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Ĭarisoprodol is excreted through breast milk. Nursing mothers should refrain from taking carisoprodol preparations.Ĭarisoprodol is taken up quite quickly by the body. The effect starts after about 30 minutes and lasts about two to six hours. It is metabolized by the liver via cytochrome P450 isoenzyme and CYP2C19. The half-life is approximately eight hours. It is excreted by the kidneys. A considerable proportion of carisoprodol is metabolized to meprobamate. The tranquilizer meprobamate is known for abuse and dependence. This explains the abuse potential of carisoprodol. The intake of carisoprodol may cause stomach upset, cause heartburn, headache, dizziness or lightheadedness. Allergic reactions are very rare on Carisoprodol. The symptoms may be occurring rash, itching, swelling his, dizziness and difficulty breathing.Ĭarisoprodol is an allergic reaction at a possible acute urticaria (hives) and described a fixed drug eruption. In neurogenic muscle spasms (cramps) and certain forms of arthritis, such as a paravertebral (next to the spine) muscle tension following a spinal degeneration.Carisoprodol relaxes the muscles. It relieves the pain of strains, sprains, spasms or other muscle injuries.Ĭarisoprodol is not a pain reliever. It should therefore not be used to treat general body aches. Carisoprodol (trade name: Soma (USA)) is a centrally acting muscle relaxant whose active metabolite is meprobamate.